P 113: Effect of Curcumin on Microglial Cells in MS
نویسنده
چکیده مقاله:
Multiple sclerosis (MS) is the most common autoimmune disease, especially among young’s. Neuroinflammation results from inflammation in CNS and it may cause different disorders and diseases .It is also known as a detriment in multiple sclerosis. In fact, it causes problems and symptoms in MS. In MS the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal cord. Demyelination causes inflammation in the area and activation of the microglial cells. Microglial cells (macrophages in nervous system) protect nervous system and they are also important in neuroinflammation especially in autoimmune condition. Microglial cells can cause inflammation in MS in these ways: Presenting of neural autoantigens to autoreactive T cells, Secreting of proinflammatory cytokines.) TNF-alpha, IL-1 beta, IL-6), increasing permeability of blood vessels, releasing nitric oxide (NO). Anti-inflammatory drugs can decrease symptoms of MS. As we know Curcumin or diferuloylmethane is a yellow pigment and principal curcuminoid of turmeric. Anti-inflammatory properties of curcumin are obtained by the control of secretion nitric acid through decreasing the level of MRNA and protein producing nitric oxide and restraining LPS that result in releasing cytokines. Regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells are decreased by curcumin. The purpose of this study is to suggest that turmeric can be as a natural herbal drug for inflammatory diseases like MS. According to the evidences , we can say turmeric, which contains curcumin can use as a prevention in MS or any diseases with inflammation like autoimmune diseases and Curcumin as an herbal matter has anti-inflammatory effects especially on microglial cells so it can be considered as a benefit dietary factor in patients with MS.
منابع مشابه
p 113: effect of curcumin on microglial cells in ms
multiple sclerosis (ms) is the most common autoimmune disease, especially among young’s. neuroinflammation results from inflammation in cns and it may cause different disorders and diseases .it is also known as a detriment in multiple sclerosis. in fact, it causes problems and symptoms in ms. in ms the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal cord. d...
متن کاملThe attenuating effect of curcumin on morphine dependence in rats: the involvement of spinal microglial cells and inflammatory cytokines
Background: New evidence suggests an important role for spinal glial cells in development of opioid dependence. Curcumin, a component of the Curcuma Longa, has shown to act as a suppressor of microglial cells. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on spinal microglial cells and inflammatory cytokines. Methods: In...
متن کاملThe attenuating effect of curcumin on morphine dependence in rats: the involvement of spinal microglial cells and inflammatory cytokines
Background: New evidence suggests an important role for spinal glial cells in development of opioid dependence. Curcumin, a component of the Curcuma Longa, has shown to act as a suppressor of microglial cells. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on spinal microglial cells and inflammatory cytokines. Methods: In...
متن کاملP 7: The Effect of Curcumin and Melittin on an Animal Model of MS
Introduction: Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is renowned through symptoms like inflammation, demyelination and the damage of neurological actions. Melittin is one of components of bee venom and has anti-neuroinflammatory effects. Curcumin also, a dietary spice from turmeric, ...
متن کاملP-113: Survey of In Vitro Effect of Resveratrol on Nitric Oxide Secretion of Human Endometrial Epithelial Cells
Background: Resveratrol is a natural polyphe- nolic compound, synthesized by plants as a phytoalexin and protects against ultraviolet radiation and fungal infection. Nitric oxide is formed from L-arginine through nitric oxide synthases (NOS), a group of enzymes that structurally resemble cytochrome P-450 reductase. In females, circulating NO is increased during follicle development and decrease...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 5 شماره 2
صفحات 144- 144
تاریخ انتشار 2017-04
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023